Coding

Part:BBa_K2619000

Designed by: shiyu liu   Group: iGEM18_XJTLU-CHINA   (2018-09-07)


STEAP3 metalloreductase/TSAP6/ferrireductase

STEAP3 metalloreductase, also known as TSAP6 encoding a ferrireductase that is involved in promoting apoptosis and exosome biogenesis. TSAP6 is a glycosylated protein presents in the trans-Golgi network, endosomal–vesicular compartment and cytoplasmic membrane (Lespagnol et al., 2008). One possible mechanism is that TSAP6 regulates its downsteam transferrin receptor genes, which is a process related to exosomal secretion. Although its detailed mechanism of promoting exosome secretion is still unknown, (Lespagnol et al., 2008) have proved that exosome production is severely compromised in TSAP6-null cells. Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 1082
    Illegal BamHI site found at 586
    Illegal BamHI site found at 1388
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI site found at 672


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Parameters
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